The discovery of a deadly virus being smuggled across the border pits FBI Special Agent James Mason and his strike force against an unknown adversary hell-bent on humanity’s destruction. In a desperate effort to contain the pathogen, they launch a predawn raid, only to find that their enemy knows they’re coming…and it’s not about to be taken alive. An explosion rips through the building, killing the majority of Mason’s team, including his partner and mentor.

Tormented by guilt, Mason returns to his home division, but he can’t seem to let go of the tragedy. He remembers seeing something inside the building before it went up in flames, something that convinces him that not only is the virus still out there, it’s merely the first stage of an even more nefarious plan. Obsessed with unraveling the plot, he launches his own investigation and uncovers a shadow organization on the brink of enacting its genocidal agenda, one carried out by a sinister mass murderer who’s been photographed at the epicenter of seemingly every historical pandemic…without appearing to age.